Difference between revisions of "Mianserine-citalopram"

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* '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
 
* '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
 
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
 
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
 +
* '''Day 8:''' stop administration of mianserine.
 
| start =   
 
| start =   
* '''Day 1:''' simultaneously start citalopram/escitalopram in a normal dosage of 20 mg/day, respectively 10 mg/day.
+
* '''Day 1:''' simultaneously start citalopram in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of mianserine and only continue administration of citalopram/escitalopram.  
 
 
* If necessary, increase the dosage of citalopram/escitalopram.  
 
* If necessary, increase the dosage of citalopram/escitalopram.  
 
| info =  
 
| info =  
* Caution with this switch is necessary, because citalopram/escitalopram slows the metabolism of mianserine via CYP2D6.}}
+
* Caution with this switch is necessary, because citalopram slows the metabolism of mianserine via CYP2D6.
 +
}}

Revision as of 23:39, 4 March 2010

Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from mianserine to citalopram.[1] [2]

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
  • Day 8: stop administration of mianserine.
Eenrichtingbord.png Start citalopram
  • Day 1: simultaneously start citalopram in a normal dosage of 20 mg/day.
  • If necessary, increase the dosage of citalopram/escitalopram.
Infobord.png More information
  • Caution with this switch is necessary, because citalopram slows the metabolism of mianserine via CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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