Difference between revisions of "Mirtazapine-amitriptyline"

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(Created page with '{{Drugswitch | from = mirtazapine | to = amitriptyline | stop = * '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day. * '''Day 1:''' reduce a dosa...')
 
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* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
 
* '''Day 0:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
 
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
 
* '''Day 1:''' reduce a dosage of 30 mg/day to 15 mg/day.
 +
* '''Day 8:''' stop administration of mirtazapine.
 
| start =
 
| start =
 
No wash-out period is needed.
 
No wash-out period is needed.
 
* '''Day 1:''' simultaneously start administration of amitriptyline in a dosage of 50 mg/day.  
 
* '''Day 1:''' simultaneously start administration of amitriptyline in a dosage of 50 mg/day.  
* '''Day 8:''' stop administration of mirtazapine and continue administration of amitriptyline. If necessary, increase dosage of amitriptyline.
+
* '''Day 8:''' If necessary, increase dosage of amitriptyline.
 
* Start low, go slow.}}
 
* Start low, go slow.}}

Revision as of 14:28, 19 June 2009

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from mirtazapine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Day 0: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
  • Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
  • Day 8: stop administration of mirtazapine.
Eenrichtingbord.png Start amitriptyline

No wash-out period is needed.

  • Day 1: simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
  • Day 8: If necessary, increase dosage of amitriptyline.
  • Start low, go slow.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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