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Type Antidepressant
Group other
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from mirtazapine to amitriptyline.

Nietinrijdenbord.png Stop mirtazapine
  • Day 0: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
  • Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
Eenrichtingbord.png Start amitriptyline

No wash-out period is needed.

  • Day 1: simultaneously start administration of amitriptyline in a dosage of 50 mg/day.
  • Day 8: stop administration of mirtazapine and continue administration of amitriptyline. If necessary, increase dosage of amitriptyline.
  • Start low, go slow.

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