Mirtazapine-maprotiline

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Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from mirtazapine to maprotiline.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Before day 1: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
  • Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
Eenrichtingbord.png Start maprotiline

No wash-out period is needed.

  • Day 1: simultaneously start administration of maprotiline in a dosage of 25-75 mg/day.
  • Day 8: stop administration of mirtazapine and continue administration of maprotiline. If necessary, increase dosage of maprotiline.
  • "Start low, go slow" is not required, but caution is necessary.
Infobord.png More information
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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