Difference between revisions of "Mirtazapine-vortioxetine"

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{{Drugswitch
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| from = mirtazapine
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| to = vortioxetine
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| stop =
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* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is  > 30 mg/day.  
 +
* '''Day 1:''' reduce the dosage of 30 mg/day to 15 mg/day.
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* '''Day 8:''' stop administration of mirtazapine.
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| start =
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* A wash-out period is not necessary.
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* '''Day 8:''' start administration of vortioxetine in a dosage of 10 mg/day.
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| info =
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
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}}

Revision as of 15:54, 4 March 2015

Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from mirtazapine to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop mirtazapine
  • Before day 1: gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
  • Day 1: reduce the dosage of 30 mg/day to 15 mg/day.
  • Day 8: stop administration of mirtazapine.
Eenrichtingbord.png Start vortioxetine
  • A wash-out period is not necessary.
  • Day 8: start administration of vortioxetine in a dosage of 10 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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