Difference between revisions of "Moclobemide-agomelatine"

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(Created page with '{{ Drugswitch | from = moclobemide | to = agomelatine | stop = * '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 3...')
 
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| to = agomelatine  
 
| to = agomelatine  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day.  
+
* '''Before day 1:''' gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day.  
 
* '''Day 1:''' reduce dosage of moclobemide to 150 mg/day.
 
* '''Day 1:''' reduce dosage of moclobemide to 150 mg/day.
 
* '''Day 8:''' stop administration of moclobemide.
 
* '''Day 8:''' stop administration of moclobemide.

Revision as of 15:24, 17 November 2009

Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from moclobemide to agomelatine.[1] [2]

Nietinrijdenbord.png Stop moclobemide
  • Before day 1: gradually reduce dosage of moclobemide to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
  • Day 1: reduce dosage of moclobemide to 150 mg/day.
  • Day 8: stop administration of moclobemide.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
  • Day 8: only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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