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Type Antidepressant
Group TCA
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline
Type Antidepressant
Group SSRI
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from nortriptyline to paroxetine.

Nietinrijdenbord.png Stop nortriptyline
  • Before day 1: gradually reduce dosage of nortriptyline to a maximum of 50 mg/day.
  • Day 1: reduce dosage of nortriptyline to 25 mg/day.
  • Day 3: reduce dosage of nortriptyline to 10 mg/day.
Eenrichtingbord.png Start paroxetine
  • Day 1: simultaneously start administration of paroxetine in a low dosage of 10 mg/day.
  • Day 8: stop administration of nortriptyline and continue administration of paroxetine in a dosage of 20 mg/day.
Infobord.png More information
  • Paroxetine is a strong inhibitor of CYP2D6, which metabolizes nortriptyline.
  • This switch is currently being reviewed.
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