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Paliperidone LA-Chlorpromazine

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Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone
Chlorpromazine
Type Antipsychotic
Group Phenothiazines
links
Medscape Chlorpromazine
PubChem 2726
PubMed Chlorpromazine
Kompas (Dutch) Chlorpromazine
Wikipedia Chlorpromazine

Switch medication from Paliperidone LA to Chlorpromazine.[1] [2]

Nietinrijdenbord.png Stop Paliperidone LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Chlorpromazine
  • Day 31-34: approx. 25% of target dose
  • Day 35-38: approx. 50% of target dose
  • Day 39-42: approx. 75% of target dose
  • Day 43: target dose
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
    Stopdepotstartafter30days.png
Nietinrijdenbord.png — Paliperidone LA
Eenrichtingbord.png — Chlorpromazine


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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