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Paliperidone LA-Olanzapine LA

Revision as of 14:52, 28 January 2013 by Sietske (talk | contribs)
Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone
Olanzapine
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Olanzapine
EMEA zypadhera
PubChem 4585
PubMed Olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Switch medication from Paliperidone LA to Olanzapine LA.[1] [2]

Nietinrijdenbord.png Stop Paliperidone LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Olanzapine LA
  • Day 31: Start depot according general dosing advice
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
    Stopdepotstartafter30depot.jpg
Nietinrijdenbord.png — Paliperidone LA
Eenrichtingbord.png — Olanzapine LA


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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