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Paliperidone LA-Sertindole

Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone
Sertindole
Type Antipsychotic
Group Atypical AP
links
PubChem 60149
PubMed Sertindole
Kompas (Dutch) Sertindole
Wikipedia Sertindole

Switch medication from Paliperidone LA to Sertindole.[1] [2]

Nietinrijdenbord.png Stop Paliperidone LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Sertindole
  • Week 1-3: approx. 25% of target dose
  • Week 4-6: approx. 50% of target dose
  • Week 7-9: approx. 75% of target dose
  • Week 10: target dose
Letopbord.png Cave
  • During this switch ECG monitoring is required because of possible QT-interval prolongation[3][4]
Infobord.png More information
StopDepotStartOral.jpg
Nietinrijdenbord.png — Paliperidone LA
Eenrichtingbord.png — Sertindole


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. SPC Sertindole (Dutch)
  4. SPC Sertindole
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