Difference between revisions of "Paroxetine-agomelatine"

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* '''Day 16:''' start agomelatine in a dosage of 25 mg/day.
 
* '''Day 16:''' start agomelatine in a dosage of 25 mg/day.
* '''Day 31:''' If necessary, gradually increase dosage of agomelatine to target dose.  
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* '''Day 31:''' If necessary, gradually increase dosage of agomelatine to target dose.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
 
| info =
 
| info =
 
* An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.
 
* An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.
 
* Low doses of paroxetine can be given by a paroxetine-solution.
 
* Low doses of paroxetine can be given by a paroxetine-solution.
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
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{{SSRI14d}}
 
{{SSRI14d}}
 
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Revision as of 13:57, 21 October 2015

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from paroxetine to agomelatine.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
  • Day 0: dosage of paroxetine is 20 mg/day.
  • Day 1: reduce dosage of paroxetine to 10 mg/day.
  • Day 8: reduce dosage of paroxetine to 5 mg/day.
  • Day 15: stop administration of paroxetine.
Eenrichtingbord.png Start agomelatine
  • Day 16: start agomelatine in a dosage of 25 mg/day.
  • Day 31: If necessary, gradually increase dosage of agomelatine to target dose.[3]
Infobord.png More information
  • An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.
  • Low doses of paroxetine can be given by a paroxetine-solution.
  • The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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