Difference between revisions of "Paroxetine-amitriptyline"

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{{stopParoxetine}}
 
{{stopParoxetine}}
 
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* '''Day 8:''' start administration of amitriptyline in a low dosage of 25-50 mg/day.  
+
* '''Day 9:''' start administration of amitriptyline in a low dosage of 25-50 mg/day.  
* '''Day 15:''' if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
+
* '''Day 16:''' if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
 
| info =  
 
| info =  
 
* Paroxetine slows the metabolism of amitriptyline via CYP2D6.  
 
* Paroxetine slows the metabolism of amitriptyline via CYP2D6.  
 
}}
 
}}

Revision as of 14:07, 28 October 2015

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from paroxetine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start amitriptyline
  • Day 9: start administration of amitriptyline in a low dosage of 25-50 mg/day.
  • Day 16: if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of amitriptyline via CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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