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Paroxetine-dosulepine

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from paroxetine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start dosulepine
  • Day 1: start administration of dosulepine in a low dosage of 25 mg/day.
  • Day 8: increase dosage of dosulepine to a dosage of 75 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of dosulepine via CYP2D6 inhibition.
  • Due to CYP inhibition a longer period of time is needed to reach steady state concentration. Please keep in mind when monitoring plasma levels
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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