Difference between revisions of "Paroxetine-imipramine"
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Revision as of 16:49, 21 October 2015
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Switch medication from paroxetine to imipramine.[1] [2]
Stop paroxetine - Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start imipramine- Day 15: start administration of imipramine in a low dosage of 25 mg/day.
- Day 22: increase administration of imipramine to a dosage of 75 mg/day.
More information- Paroxetine slows the metabolism of imipramine via CYP1A2 and CYP2D6.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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