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| from = paroxetine
| to = maprotiline
| stop = * '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. * '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. * '''Day 8:''' reduce dosage Decrease with about 25% of paroxetine to 5 mg/day.original dose every 3-4 days
| start =
Caution is necessary.
* '''Day 81:''' simultaneously start administration of maprotiline in a low dosage of 25 mg/day. * '''Day 15Stop paroxetine:''' stop administration of paroxetine and only continue increase administration of maprotiline in to a dosage of 50-100 mg/day.* "Start low, go slow" is not required, but caution is necessary!
| info =
* Paroxetine slows the metabolism of maprotiline via CYP1A2 and CYP2D6. * {{SSCYPinh}}* {{TCAplasmalevelmonitoring}}}}