Paroxetine-nortriptyline

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paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from paroxetine to nortriptyline.

Nietinrijdenbord.png Stop paroxetine
  • Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
  • Day 0: dosage of paroxetine is 20 mg/day.
  • Day 1: reduce dosage of paroxetine to 10 mg/day.
  • Day 8: reduce dosage of paroxetine to 5 mg/day.
  • Day 15: stop administration of paroxetine.
Eenrichtingbord.png Start nortriptyline
  • Day 15: start administration of nortriptyline in a low dosage of 25 mg/day.
  • Day 22: continue nortriptyline in a dosage of 50 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of nortriptyline via CYP2D6.
  • This switch is currently being reviewed.
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