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Paroxetine-trazodone

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from paroxetine to trazodone.

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start trazodone
  • Day 9: start trazodone in dosage of 100-150 mg/day.
  • Day 16: If necessary, increase the dosage of trazodone every 3-4 days with 50 mg to a maximum of 400 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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