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Sertindole-Flupenthixol LA

Sertindole
Type Antipsychotic
Group Atypical AP
links
PubChem 60149
PubMed Sertindole
Kompas (Dutch) Sertindole
Wikipedia Sertindole
Flupenthixol
long acting
Type Antipsychotic
Group Thioxanthenes
links
Medscape Flupenthixol
PubChem 17012
PubMed Flupenthixol
Kompas (Dutch) Flupenthixol
Wikipedia Flupenthixol

Switch medication from Sertindole to Flupenthixol_LA.

Nietinrijdenbord.png Stop Sertindole
  • Week 1-3: approx. 75% of initial dose
  • Week 4-6: approx. 50% of initial dose
  • Week 7-9: approx. 25% of initial dose
  • Week 10: stop
Eenrichtingbord.png Start Flupenthixol_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)
Letopbord.png Cave
  • During this switch ECG monitoring is required because of possible QT-interval prolongation[1][2]
Infobord.png More information
  • Alternatively, first switch to oral form and then switch to depot to manage possible (adverse) reactions. With a direct switch to a depot it is advisable to administer a low testdose in order to exclude adverse reactions.
    Stop10WeeksStartDepot.jpg
Nietinrijdenbord.png — Sertindole
Eenrichtingbord.png — Flupenthixol_LA


  1. SPC Sertindole (Dutch)
  2. SPC Sertindole
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