Difference between revisions of "Sertraline-agomelatine"

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| to = agomelatine  
 
| to = agomelatine  
 
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* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.  
+
* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.  
 
* '''Day 1:''' reduce dosage of sertraline to 50 mg/day.
 
* '''Day 1:''' reduce dosage of sertraline to 50 mg/day.
 
* '''Day 8:''' reduce dosage of sertraline to 25 mg/day.
 
* '''Day 8:''' reduce dosage of sertraline to 25 mg/day.

Revision as of 15:25, 17 November 2009

Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from sertraline to agomelatine.[1] [2]

Nietinrijdenbord.png Stop sertraline
  • Before day 1: gradually reduce dosage of sertraline to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of sertraline to 50 mg/day.
  • Day 8: reduce dosage of sertraline to 25 mg/day.
  • Day 15: stop administration of sertraline.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.
  • Day 15: continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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