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| stop =
* '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
* '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day.* '''Day 8:''' stop administration of sertraline.
| start =
Caution is necessary.
* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of sertraline and only continue administration of amitriptyline in a dosage of 50 mg/day.
* Start low, go slow!
| info =
* Sertraline dose-dependently slows the metabolism of amitriptyline via CYP2D6. }}
