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Sertraline-doxepine

510 bytes removed, 14:14, 30 June 2023
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| to = doxepin
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* '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day. {{TCAdecrease25p3d}}
| start =
Caution is necessary.* '''Day 1:''' simultaneously start administration of doxepin in a low dosage of 25 mg/day. * '''Day 8:''' stop administration of sertraline and only continue administration of doxepin only. If necessary, increase dosage of doxepin.* "Start low, go slow" is not required, but caution is necessary.{{TCAincrease25p3d}}| info = * Sertraline dose-dependently slows the metabolism of doxepin via CYP2D6. {{TCAplasmalevelmonitoring}}}}