- Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. [1]
- Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.[2][3]
- Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory). [2][3]
- These two agents have less significant pharmacologic interactions than do lamotrigine and valproate [2][3]