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  • The combination may rarely cause neurotoxicity without increased plasma levels. [1]
  • The combination of these two drugs in generally safe and effective, but it should be avoided for patients with comorbid CNS (central nervous system) disease. Cases of neurotoxicity and asterixis have been reported with the concomitant use of lithium and carbamazepine.[2]
  • Marcoux AW. Carbamazepine-lithium drug interaction. Ann Pharmacother 1996;30:547
  • Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21