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Type Antidepressant
Group MAO-I
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine
Type Antidepressant
Group TCA
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from tranylcypromine to amitriptyline.

Nietinrijdenbord.png Stop tranylcypromine
  • Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
  • When a dosage of 10 mg/day is reached, stop administration.
Eenrichtingbord.png Start amitriptyline
  • Day 1-14: a wash-out period of two weeks is necessary.
  • Day 15: start amitriptyline after this period in a low dosage of 25-50 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is possible without a wash-out period.
  • The wash-out period is necessary for the MAO enzymes to restore their function.
  • This switch is currently being reviewed.
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