Difference between revisions of "Tranylcypromine-vortioxetine"

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{{Drugswitch
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| from = tranylcypromine
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| to = vortioxetine
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| stop =
 +
* '''Before day 1:''' gradually reduce dosage of tranylcypromine with 10-20 mg/week.  
 +
* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
 +
| start =
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* '''Day 1-14:''' a wash-out period of two weeks is necessary.
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* '''Day 15:''' start administration of vortioxetine in a normal dosage of 10 mg/day.
 +
| info =
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 +
* The wash-out period is necessary for the MAO enzymes to restore their function.
 +
}}

Revision as of 16:17, 4 March 2015

Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from tranylcypromine to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Before day 1: gradually reduce dosage of tranylcypromine with 10-20 mg/week.
  • Day 1: when a dosage of 10 mg/day is reached, stop administration
Eenrichtingbord.png Start vortioxetine
  • Day 1-14: a wash-out period of two weeks is necessary.
  • Day 15: start administration of vortioxetine in a normal dosage of 10 mg/day.
Infobord.png More information
  • Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
  • The wash-out period is necessary for the MAO enzymes to restore their function.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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