Difference between revisions of "Trazodone-hypericum"

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* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
+
* '''Before day 1:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
 
* '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day.
 
* '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day.
 
* '''Day 8:''' stop administration of trazodone.
 
* '''Day 8:''' stop administration of trazodone.

Revision as of 16:06, 20 November 2009

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from trazodone to hypericum.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 75-100 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start hypericum
  • Day 8-14: a wash-out period of one week is necessary.
  • Day 15: start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).
Infobord.png More information
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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