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Trazodone-tranylcypromine

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from trazodone to tranylcypromine.

Nietinrijdenbord.png Stop trazodone
  • Before day 1: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 3: reduce dosage of trazodone to 50 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start tranylcypromine
  • Day 8-10: a wash-out period of 3 days is necessary.
  • Day 11: start administration of tranylcypromine in a dosage of 20 mg/day.
  • If necessary, increase dosage of tranylcypromine.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
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