Changes

* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day. {{stopVenlafaxine}}

* '''Day 1:''' simultaneously start administration of amitriptyline agomelatine in a low dosage of 25 mg/day. * '''Day 8:''' stop administration of venlafaxine and continue administration of amitriptyline in a agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.  <ref name="agoswitch"> {{Pubmed|20196187| info = * “Start low, go slow” for amitriptyline, and caution with this switch is necessaryMcAllister-Williams RH et al. * Venlafaxine is a weak inhibitor The use of CYP2D6, which metabolizes amitriptylineantidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol.2010 Mar 1;25(2):95-102}}</ref>}}