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Type Antidepressant
Group SNRI
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Type Antidepressant
Group other
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from venlafaxine to agomelatine.

Nietinrijdenbord.png Stop venlafaxine
  • Day 0: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
  • Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: stop administration of venlafaxine and continue administration of amitriptyline in a dosage of 50 mg/day.
Infobord.png More information
  • “Start low, go slow” for amitriptyline, and caution with this switch is necessary.
  • Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.
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