Difference between revisions of "Venlafaxine-amitriptyline"

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(Created page with '{{Drugswitch | from = venlafaxine | to = amitriptyline | stop = * '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day. * '''Day 1:''' reduce a dosa...')
 
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* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
 
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
 
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
 +
* '''Day 8:''' stop administration of venlafaxine.
 
| start =  
 
| start =  
 
* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.  
 
* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.  
* '''Day 8:''' stop administration of venlafaxine and continue administration of amitriptyline in a dosage of 50 mg/day.
+
* '''Day 8:''' continue administration of amitriptyline in a dosage of 50 mg/day.
 
| info =  
 
| info =  
 
* “Start low, go slow” for amitriptyline, and caution with this switch is necessary.  
 
* “Start low, go slow” for amitriptyline, and caution with this switch is necessary.  
 
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.}}
 
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.}}

Revision as of 12:15, 24 June 2009

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from venlafaxine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Day 0: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
  • Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
  • Day 8: stop administration of venlafaxine.
Eenrichtingbord.png Start amitriptyline
  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
Infobord.png More information
  • “Start low, go slow” for amitriptyline, and caution with this switch is necessary.
  • Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes amitriptyline.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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