Difference between revisions of "Vortioxetine-clomipramine"

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* ''' Day 9:''' start with 25 mg/day of clomipramine.
 
* ''' Day 9:''' start with 25 mg/day of clomipramine.
 
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{{Day22NoBloodlevelvortioxetine}}<ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
 
| info =
 
| info =
 
* {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>
 
* {{theorSS}}<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>
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}}
 
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Revision as of 15:04, 4 November 2015

Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from vortioxetine to clomipramine.[1] [2]

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start clomipramine
  • No wash-out period is needed.
  • Day 9: start with 25 mg/day of clomipramine.
  • Titrate slowly
  • Day 22: bloodlevel vortioxetine is now zero, so you can increase faster. [3] [4]
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.[5]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54
  4. KNMP; Informatorium Medicamentorum 2023; Monografie "vortioxetine" (Dutch)
  5. European Medicines Agency | SmPC Brintellix 5 mg.
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