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Zuclopenthixol LA-Rest AP

Zuclopenthixol
long acting
Type Antipsychotic
Group Thioxanthenes
links
PubChem 5311507
PubMed Zuclopenthixol
Kompas (Dutch) Zuclopenthixol
Wikipedia Zuclopenthixol
{{:Rest AP[1] }}

Switch medication from Zuclopenthixol_LA to Rest AP[1].[2] [3]

Nietinrijdenbord.png Stop Zuclopenthixol_LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Rest AP[1]
  • t= 0 Start dosing 25% of the target dose on the day you normally would have injected the former depot.
  • t= 1 x T1/2 of depot approx. 50% of target dose
  • t= 2 x T1/2 of depot approx. 75% of target dose
  • t= 3 x T1/2 of depot approx. 100% of target dose
  • See 'more information' for the T1/2 of this depot
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[4]
  • the T1/2 of zuclopenthixol depot is approximately 21 days.[5]
  1. A. Risselada, Switchen van en naar depotantipsychotica - een update; Psyfar, june 2022 nummer 2
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  4. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
  5. KNMP Kennisbank, informatorium medicamentorum: Zuclopenthixol
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[[Category:SwitchRest AP[1]]]