Difference between revisions of "Zuclopenthixol MA-Paliperidone LA"

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Revision as of 14:38, 15 February 2010

Zuclopenthixol
Medium long acting
Type Antipsychotic
Group Thioxanthenes
links
PubChem 5311507
PubMed Zuclopenthixol
Kompas (Dutch) Zuclopenthixol
Wikipedia Zuclopenthixol
Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone

Switch medication from Zuclopenthixol_MA to Paliperidone_LA.[1] [2]

Nietinrijdenbord.png Stop Zuclopenthixol_MA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Paliperidone_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)

Paliperidone palmitate is since spring 2011 approved by EMEA: therefore this switch is under construction.

Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  • Zuclopenthixol_MA = Zuclopenthixol acetate [4]
    Empty.jpg
Nietinrijdenbord.png — Zuclopenthixol_MA
Eenrichtingbord.png — Paliperidone_LA


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
  4. SPC Zuclopenthixol acetate
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