Bupropion-fluvoxamine

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Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from bupropion to fluvoxamine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
  • Day 1: Stop administration of bupropion
Eenrichtingbord.png Start fluvoxamine
  • Day 2: Start fluvoxamine in normal dosage of 50 mg/day.
  • After 3 weeks: If necessary increase dosage gradually to 100-300 mg/day
Infobord.png More information
  • No wash-out period is needed.
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
  • Pharmacokinetic interaction is not important because of low plasma levels.
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