Bupropion-nortriptyline

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Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Nortriptyline
Type Antidepressant
Group TCA
links
Medscape Nortriptyline
PubChem 4543
PubMed Nortriptyline
Kompas (Dutch) Nortriptyline
Wikipedia Nortriptyline

Switch medication from bupropion to nortriptyline.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
  • Day 1: reduce dosage of bupropion to 150 mg/day.
  • Day 8: stop administration of bupropion.
Eenrichtingbord.png Start nortriptyline
  • Day 1: Start and increase the dose with about 25% of the target dose every 3 days.
  • Start administration of nortriptyline in a low dosage of 25 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of nortriptyline via CYP2D6.
  • Caution is necessary at the start of administration of nortriptyline.
  • The concomitant use of bupropion and tricyclic antidepressants (TCAs) may potentiate the risk of seizures. These agents are all epileptogenic and may have additive effects on the seizure threshold.
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