Bupropion-paroxetine

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Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from bupropion to paroxetine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
  • Day 1: Stop administration of bupropion
Eenrichtingbord.png Start paroxetine
  • Day 2: Start paroxetine in normal dosage of 20 mg/day.
  • After 3 weeks: If necessary increase dosage gradually to 30-50 mg/day.
Infobord.png More information
  • No wash-out period is needed.
  • Bupropion slows the metabolism of paroxetine by CYP2D6.
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
  • The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
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