Bupropion-vortioxetine

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Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from bupropion to vortioxetine.

Nietinrijdenbord.png Stop bupropion
  • Day 1: reduce dosage of bupropion to 150 mg/day.
  • Day 8: stop administration of bupropion.
Eenrichtingbord.png Start vortioxetine
  • Day 8-14: a wash-out period of 1 week is necessary.
  • Day 15: start administration of vortioxetine in a normal dosage of 10 mg/day.
Infobord.png More information
  • Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually. Bupropion is an inhibitor of CYP2D6.
  • Vortioxetine is recently marketed, so in future more data wille become available (test for VJC 2015)
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