Combining-Carbamazepine-Gabapentin
From Psychiatrienet
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Adding gabapentin to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Gabapentin is eliminated unchanged by the kidney for 100%.
Start gabapentin- Start gabapentin according to the general dosing advice. Coadministration of carbamazepine with gabapentin appears to be safe, with no significant interactions. Dose adjustments and additional blood level monitoring are not necessary.[5]
Cave- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects.[6]
- Jump up ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- Jump up ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ Jump up to: 3.0 3.1 Farmacotherapeutisch Kompas - carbamazepine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content - Jump up ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
- Jump up ↑ Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
- Jump up ↑ Interactions between carbamazepine and gabapentin on drugs.com
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