Combining-Lamotrigine-Olanzapine

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Lamotrigine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX09
PubChem 3878
PubMed Lamotrigine
Drugs.com lamotrigine
Kompas (Dutch) Lamotrigine
Wikipedia Lamotrigine
Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Adding olanzapine to lamotrigine.

Infobord.png General information
  
Lamotrigine
  • Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
  
Olanzapine
  • Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
  
Lamotrigine
  
Olanzapine
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start olanzapine
  
Olanzapine
  • Start lamotrigine according to the general dosing advice.
Nietinrijdenbord.png Stop olanzapine
  
Olanzapine
Letopbord.png Cave
  • Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. [3]


  1. 1.0 1.1 Farmacotherapeutisch Kompas; Toxicologie (dutch) Cite error: Invalid <ref> tag; name "ftktox" defined multiple times with different content
  2. Farmacotherapeutisch Kompas - lamotrigine (dutch)
  3. 3.0 3.1 Drugs.com lamotrigine Cite error: Invalid <ref> tag; name "drugscom" defined multiple times with different content
  4. 4.0 4.1 4.2 4.3 KNMP; Informatorium Medicamentorum 2015; Monografie "olanzapine" (Dutch)
  5. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
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