Adding risperidone to quetiapine.
- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. 
- KNMP; Informatorium Medicamentorum 2015; Monografie "quetiapine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content
- NVZA; Toxicology.org; Monografie 73 (dutch)
- Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- Drugs.com quetiapine-fumarate
- Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- Interactions between risperidone and quetiapine on drugs.com
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