Adding ziprasidone to quetiapine.
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- Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
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- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- The combination of these 2 antipsychotics seems to be irrational from a pharmacotherapeutical point of view.
- Quetiapine may have additive adverse cardiovascular effects in combination with other drugs that are known to prolong the QT interval of the electrocardiogram. 
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