Adding lithium to risperidone.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination may have additive side effects.
- Start lithium according to the general dosing advice.
- The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.
- KNMP; Informatorium Medicamentorum 2015; Monografie "risperidon" (Dutch)
- Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
- Farmacotherapeutisch Kompas - lithium (dutch)
- Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21
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