Combining-Valproic acid-Aripiprazole

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Valproic acid
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AG01
PubChem 3121
PubMed acid%22 Valproic acid
Drugs.com valproic-acid
Kompas (Dutch) Valproic acid
Wikipedia Valproic acid
Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole

Adding aripiprazole to valproic acid.

Infobord.png General information
  • Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
  • Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.

 

Eenrichtingbord.png Start aripiprazole
  • Start according to the general dosing advice.
Letopbord.png Cave
  • Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.[4]
  • Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. [5]


  1. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  2. Farmacotherapeutisch Kompas - valproinezuur (dutch)
  3. KNMP; Informatorium Medicamentorum 2023; Monografie "valproaat" (Dutch)
  4. Interactions between aripiprazole and valproic acid on drugs.com
  5. Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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