Doxepine-sertraline

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Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin
Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline

Switch medication from doxepin to sertraline.

Nietinrijdenbord.png Stop doxepin
  • Before day 1: gradually reduce dosage of doxepin to a maximum of 100 mg/day, when this dosage is > 100 mg/day.
  • Day 1: reduce dosage of doxepin to 50 mg/day.
  • Day 8: reduce dosage of doxepin to 25 mg/day.
  • Day 15: stop administration of doxepin.
Eenrichtingbord.png Start sertraline
  • Day 16: start administration of sertraline in a normal dosage of 50 mg/day.
  • Day 23: if necessary increase sertraline to 100 mg/day.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Sertraline is a weak inhibitor of CYP2D6, which metabolizes doxepin.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2015; Monografie "doxepine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 63 (dutch)
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