Duloxetine-dosulepine

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from duloxetine to dosulepine.

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start dosulepine
  • Day 9: start administration of dosulepine in a low dosage of 25 mg/day.
  • Day 16: and increase the dosage of dosulepine to 50-75 mg/day.
Infobord.png More information
  • Duloxetine slows the metabolism of dosulepine by CYP2D6.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
  2. NVZA; Toxicology.org; Monografie 63 (dutch)
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