Duloxetine-fluvoxamine

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine

Switch medication from duloxetine to fluvoxamine.

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start fluvoxamine
  • Day 11: start fluvoxamine 50 mg.
  • Day 15: increase administration of fluvoxamine.
Infobord.png More information
  • Fluvoxamine inhibits the metabolism of duloxetine through CYP1A2.[1]
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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