Duloxetine-maprotiline

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from duloxetine to maprotiline.

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start maprotiline

No wash-out period is needed.

  • Day 8: start administration of maprotiline in a low dosage of 25 mg/day.
  • Day 15: increase the dosage of maprotiline to 50 mg/day.
Infobord.png More information
  • Duloxetine slows the metabolism of maprotiline by CYP2D6.
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