Duloxetine-paroxetine

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Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from duloxetine to paroxetine.

Nietinrijdenbord.png Stop duloxetine
  • Before day 1: gradually reduce dosage of duloxetine to a maximum of 60 mg/ day, when this dosage is > 60 mg/day.
  • Day 1: reduce dosage of duloxetine to a maximum of 30 mg/day.
  • Day 8: stop administration of duloxetine.
Eenrichtingbord.png Start paroxetine
  • Day 9: start paroxetine in a normal dosage of 20 mg/day.
Infobord.png More information
  • Paroxetine and duloxetine slow each others metabolism by CYP2D6-inhibition.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
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