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Type Antidepressant
Group SSRI
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Type Antidepressant
Group other
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine

Switch medication from fluoxetine to mianserine.

Nietinrijdenbord.png Stop fluoxetine
  • Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start mianserine

No wash-out period is needed.

  • Day 1: start mianserine the next day in low dosage of 30 mg/day.
  • Day 21: increase dosage of mianserine to normal, 60 mg/day.
Infobord.png More information
  • (Desmethyl)Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.
  • Fluoxetine slows the metabolism of mianserine through CYP2D6.
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