Fluoxetine-mirtazapine

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Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from fluoxetine to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop fluoxetine
  • Day 1: Stop fluoxetine
Eenrichtingbord.png Start mirtazapine
  • Day 5: Start with 50% of the target dose
  • Day 10: Increase dose to 100% of the target dose
  • Day 11 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose mirtazapine = 15 mg
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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